Glyoxalase 1 is a proadipogenic gene.

ABSTRACT: Diabetes is one of the most prevalent and widespread diseases, with the majority of cases stemming from prolonged obesity. Obesity occurs through the expansion of adipose tissue in an unhealthy and dysfunctional manner, where patients develop inflammation and insulin resistance. Diabetic patients have increased levels of the reactive glycolytic byproduct, methylglyoxal (MGO), and its resulting post-translational modifications (PTMs) compared with nondiabetic patients. To combat this, cells are equipped with the glyoxalase cycle, consisting of two enzymes, glyoxalase 1 (GLO1) and GLO2, to reduce the levels of MGO. Previous work has identified a putative role for MGO in the pathologies associated with obesity. We thus sought to interrogate the role of GLO1 in the context of adipogenesis usin

SUBMITTER: Trujillo MN 

PROVIDER: S-EPMC12756636 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature