Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation.

ABSTRACT:

Background

Although significant progress has been made in the treatment of biliary tract tumors (BTC), most patients still respond poorly to existing therapies. Therefore, the development of new therapeutic targets and drugs remains an urgent need. Previous studies have extensively applied multi-omics approaches to identify pathogenic targets and drug candidates; however, experimental validation has often been insufficient.

Methods

To identify therapeutic targets associated with biliary tract tumors (BTC), we performed Mendelian randomization (MR) analyses integrating cis-eQTL data of druggable genes with BTC GWAS datasets to determine potential therapeutic targets. Subsequently, drug repurposing analyses were conducted to identify candidate compounds corresponding to these

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12756669 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature