Polymer-Coated Iron Oxide Nanoparticles as an Effective Tool for Histamine Extraction: Synthesis, Characterization, and Application.

ABSTRACT: Histamine accumulation in food products poses significant health risks, necessitating efficient removal strategies to ensure food safety and quality. This study presents the synthesis, characterization, and optimization of poly-(acrylic acid-co-methacrylic acid)-coated iron oxide nanoparticles [ION@P-(AA-co-MAA)] as adsorbents for histamine extraction from food-mimicking buffers. Using a combined Plackett-Burman and central composite design approach, we identified the monomer-to-iron oxide nanoparticle (IONP) ratio and polymerization temperature as critical synthesis parameters significantly influencing nanoparticle size (hydrodynamic diameter ranging from 182 to 801 nm), surface charge (ζ potential from -39.1 to -23.8 mV), polymer coating thickness (weight loss between 3.3%

SUBMITTER: Reindl M 

PROVIDER: S-EPMC12756767 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature