Study of Adsorption Behavior of Uric Acid on Gold Nanoparticles.

ABSTRACT: Hyperuricemia is commonly associated with gout, diabetes, stroke, coronary heart disease, uric acid (UA) nephrolithiasis, and renal dysfunction. It can induce kidney damage, exacerbate atherosclerosis, and accelerate the onset and progression of cardiovascular and cerebrovascular diseases. In this study, a coreduction method with tannic acid and trisodium citrate dihydrate was utilized to synthesize spherical gold nanoparticles (AuNPs) with a size of 4.10 nm-13.77 nm in diameter. The toxicity of these nanoparticles on human normal pulmonary epithelial cells (BEAS-2B) was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) method. Owing to their nontoxicity and excellent adsorption performance, AuNPs were employed as an adso

SUBMITTER: Wang T 

PROVIDER: S-EPMC12756768 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature