Chalcone Derivatives: Antioxidant Activity, Photoprotective Properties, and Stability under UV Irradiation.

ABSTRACT: The development of multifunctional photoprotective agents capable of combining ultraviolet (UV) radiation absorption, photostability, and antioxidant activity represents a major challenge in cosmetic science. In this study, a series of 14 chalcone derivatives was synthesized and evaluated for their antioxidant and photoprotective potential. The chalcones, synthesized via the Claisen-Schmidt condensation, were evaluated for their antioxidant activity through DPPH, FRAP, and cyclic voltammetry assays, revealing that compounds 6, 7, and 12 exhibited the highest free radical scavenging capacity, reducing power, and inhibition of lipid peroxidation, with electrochemical data confirming facile oxidation via proton-coupled electron transfer. Photoprotective assessment by the Mansur method demonst

SUBMITTER: Guaringue RP 

PROVIDER: S-EPMC12756833 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature