Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits.

ABSTRACT: Glycogen storage disease III (GSD-III) is caused by an inherited deficiency of the glycogen debranching enzyme. Affecting the liver, muscle and heart, GSD-IIIa is the most common GSD-III subtype. We evaluated the feasibility and safety of a physical exercise intervention in patients with GSD-IIIa and its effects at the multisystem level. Nine patients (four female; five children and four adults; 60% of all diagnosed Spanish patients) participated in a 12 week home-based, remotely supervised programme combining moderate-intensity endurance and resistance exercises. Training tolerance/adaptation (fatigue severity scale, wellbeing questionnaire) and safety were assessed throughout the intervention period. The following outcomes were determined at baseline and postintervention: Health-related

SUBMITTER: Bustos-Sellers A 

PROVIDER: S-EPMC12756873 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature