<i>Adlercreutzia</i>-modulated polyunsaturated fatty acid metabolism underlies nicotine's anti-obesity effects.

ABSTRACT:

Background

The regulatory effects of nicotine on energy balance through central and peripheral mechanisms have been reported. However, its impact on obesity and gut microbiota at safe doses remains unclear.

Results

In this study, it was found that chronic oral nicotine administration daily at relative low dose (0.5 mg/kg) significantly alleviated high-fat diet (HFD)-induced obesity phenotypes in mice, including body weight gain, fat deposits, hepatic steatosis, inflammation and metabolic dysfunction. Gut microbiota depletion and fecal microbiota transplantation (FMT) confirmed that these beneficial effects were microbiota-dependent. Metagenomic sequencing confirmed that nicotine administration reshaped gut microbiota composition, and specifically enriched the commensal genus

SUBMITTER: Duan Y 

PROVIDER: S-EPMC12756887 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature