Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model.

ABSTRACT:

Introduction

Obesity is increasing globally, and it negatively impacts influenza vaccine efficacy. Although sex differences in influenza vaccine responses are studied in non-obese hosts, studies investigating sex differences in influenza vaccine-induced immunity and protection during obesity are limited.

Materials and methods

Using the C57BL/6J mouse model of high-fat diet (HFD)-induced obesity or low-fat diet controls, we investigated sex differences in influenza vaccine-induced immunity and protection during obesity. Male and female mice with or without obesity were vaccinated intramuscularly twice at a 3-week interval with an inactivated 2009 H1N1 influenza A virus (IAV) vaccine. At 35 days post-vaccination (dpv), antibody responses in plasma and B- and T-cell responses i

SUBMITTER: Wolfe B 

PROVIDER: S-EPMC12756896 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature