Longitudinal associations between medication use and phenotypic aging: insights from the Baltimore longitudinal study of aging.

ABSTRACT:

Background

Limited population-based data exist on the association between medication use and changes in phenotypic aging. This study investigated these associations using data from the Baltimore Longitudinal Study of Aging.

Methods

Phenotypic aging (PA) markers were constructed using the Klemera-Doubal method across four domains: body composition (structural and metabolic changes), energetics (energy generation and utilization capacity), homeostatic mechanisms (internal stability maintenance), and neuroplasticity/neurodegeneration (nervous system function and decline). Associations between 27 common drug categories and changes in these PA markers were analyzed using conditional generalized estimating equations (cGEE), focusing on within-individual variation to control for ge

SUBMITTER: Tang B 

PROVIDER: S-EPMC12756985 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature