Real-time near-infrared II fluorescence navigation of magnetic nanorobots for image-guided therapy.

ABSTRACT: Real-time navigation of nanorobots with high spatiotemporal resolution and molecular contrast in deep tissues via noninvasive manners has been challenging. Here, we developed near-infrared II (NIR-II; 1000 to 3000 nanometers) magnetic nanorobots that balance fluorescence brightness at ~1600 nanometers with magnetic strength, facilitating precise gathering or locomotion of the nanorobots in the peritoneal cavity, hindlimb, liver, spleen, and lower gastrointestinal tract of live mice under real-time NIR-II imaging guidance with high resolution and sensitivity. Two-plex NIR-II imaging enabled precise locomotion by simultaneously providing real-time information on both the location of nanorobots and the position of target sites with molecular specificity. NIR-II magnetic nanorobots remained st

SUBMITTER: Dai Z 

PROVIDER: S-EPMC12757035 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature