Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers.

ABSTRACT: Biological potassium channels exemplify nature's precision in ion discrimination, governing critical processes such as osmotic regulation and neuronal signaling. Developing artificial potassium channels with biological-level and dynamic selectivity is of fundamental importance for intelligent nanofluidic devices. Here, we present a biomimetic mechanoresponsive potassium channel using telechelic polymers with 18-crown-6 and 2-ureido-4-pyrimidinone terminals, achieving a record potassium/sodium selectivity of 104.7. Quadruple hydrogen-bonded supramolecular networks enable both membrane elasticity and pressure-responsive crown ether aggregation state modulation. Mechanical deformation induces a structural reconfiguration that decelerates potassium conduction while accelerating sodium transpor

SUBMITTER: Li C 

PROVIDER: S-EPMC12757039 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature