Site-specific phosphorylation of LRP regulates <i>FLC</i> chromatin looping and flowering.

ABSTRACT: Emerging evidence suggests that multiple RNA recognition motif (RRM)-containing proteins are involved in transcriptional regulation, yet the underlying mechanisms remain largely unclear. Here, we show that the previously uncharacterized LATE-FLOWERING RRM-CONTAINING PROTEIN (LRP) prevents 5'-3' chromatin looping of the key floral repressor gene FLOWERING LOCUS C (FLC) via direct association with its 5' and 3' genomic regions. Loss of LRP function leads to increased 5'-3' gene looping, reduced RNA polymerase II (Pol II) occupancy at the FLC locus, thereby increasing FLC transcription and delaying flowering in Arabidopsis thaliana. Furthermore, site-specific phosphorylation of LRP at serine 17, mediated by the kinase PRP4KA, is essential for LRP prot

SUBMITTER: Fan S 

PROVIDER: S-EPMC12757049 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature