Neuronal heterogeneity of normalization strength in a circuit model.

ABSTRACT: Neurons in higher-order visual areas integrate information through a canonical computation called normalization. The strength of normalization is highly heterogeneous across neurons, and this heterogeneity correlates with attention-mediated modulations in neural responses. However, the circuit mechanism underlying the heterogeneous normalization strength is unclear. In this work, we study normalization in a spiking neuron network model of visual cortex. Our model reveals that the heterogeneity of normalization strength is highly correlated with the inhibitory current each neuron receives. The correlation between inhibition and other synaptic inputs explains the experimentally observed dependence of spike count correlations on normalization strength. Further, we find that neurons with stron

SUBMITTER: Song D 

PROVIDER: S-EPMC12757059 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature