Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F.

ABSTRACT: Autoimmune uveitis (AU) is a category of sight-threatening diseases with different pathological causes. Transcriptomic analysis of patients with AU revealed a highly oxidative stress profile as well as an up-regulated apolipoprotein E (APOE) expression in their peripheral blood mononuclear cells (PBMCs). In addition, single-cell RNA sequencing of retinal microglia also identified an up-regulated expression of APOE in a murine model of experimental AU (EAU). Our results and others previously suggested that microglia are tightly associated with the development of AU. Meanwhile, although APOE has been reported to play a myriad of functions ranging from lipid metabolism to neural regeneration, little is known about its detailed mechanism in the development of AU. In

SUBMITTER: Zeng S 

PROVIDER: S-EPMC12757062 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature