L-Type Ca_v1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines.

ABSTRACT:

Background

The ionic mechanism by which catecholamines increase the heart rate is incompletely understood. In this study, we have assessed the roles of sinoatrial node L-type Ca_v1.3 (α_1D) Ca²⁺ channels, phosphorylation of L-type channel regulatory partner protein Rad (Ras-related RGK GTP-binding protein), and cAMP-dependent regulation of hyperpolarization-activated HCN (hyperpolarization-activated cyclic nucleotide-gated) channels.

Methods

We studied β-adrenergic regulation of heart rate and sinoatrial pacemaker activity in mice lacking Ca_v1.3 channels and in mice expressing dihydropyridine-insensitive L-type Ca_v1.2 channels alone or concomitantly expressing cAMP-insensitive HCN4 subunits in a heart-specific and time-con

SUBMITTER: Torre E 

PROVIDER: S-EPMC12757128 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature