Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue.

ABSTRACT: Development of strategies to prevent severe dengue has been challenging, partly by our incomplete understanding of a protective immune response after dengue virus (DENV) infection. To define adaptive immune signatures associated with protection from hospitalized dengue, we performed in-depth single-cell immunoprofiling and quantified DENV-specific T cells in subclinical or hospitalized dengue-infected children. Individuals with subclinical infection exhibit clonally expanded CD4⁺ TEMRA cells, increased frequency of DENV-specific CD4⁺ T cells, and demonstrate a gene expression signature of increased Treg functionality. Across all T cell subsets, subclinical cases upregulated a type I IFN response gene signature. In contrast, expanding CD8⁺ EM cells from hosp

SUBMITTER: Gonnella G 

PROVIDER: S-EPMC12757132 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature