Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity-Matched Analysis.

ABSTRACT:

Objective

The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage more than that within the standard duration.

Methods

We enrolled 352 consecutive patients from one hospital who underwent pancreaticoduodenectomy following biliary drainage between 2010 and 2023. The patients were prospectively assigned to two groups according to prophylactic antibiotic duration. In the standard duration group (2010-2013; 112 patients), the duration was within 24 h postoperatively. In the prolonged duration group (2014-2

SUBMITTER: Matsumoto K 

PROVIDER: S-EPMC12757157 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature