Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study.

ABSTRACT:

Aim

We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors while also evaluating the effectiveness of neoadjuvant and adjuvant chemotherapy.

Methods

We retrospectively analyzed clinicopathological and follow-up data from 1068 PDAC patients who underwent surgical resection at 13 Kyushu Study Group institutions (January 2016-December 2020). Patients were categorized into two groups: without (Group A) or with (Group B) unexpected postoperative noncurative factors. Kaplan-Meier analysis assessed disease-free and overall survival, while univariate and multivariate analyses using the Cox proportional hazards model identified prognostic factors.

Results

Group B (

SUBMITTER: Matsui H 

PROVIDER: S-EPMC12757158 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature