Impact of Sarcopenia During Induction Treatment in Patients With Unresectable Locally Advanced Pancreatic Cancer.

ABSTRACT:

Background

Chemotherapeutic advances have increased opportunities for conversion surgery (CS) in unresectable locally advanced (UR-LA) pancreatic cancer (PC). However, the optimal indications for CS remain unclear. Sarcopenia has been associated with poor outcomes in PC, except UR-LA PC. Herein, we aimed to evaluate the impact of sarcopenia on the prognosis of patients with UR-LA PC.

Methods

In this retrospective study, we reviewed consecutive patients with UR-LA PC who had received chemo(radio)therapy as an initial treatment between 2015 and 2023. We examined relevant clinical variables and CT findings at initial diagnosis and at 6 months after starting treatment.

Results

Ten of the 41 patients had undergone CS. Tumor size at 6 months, clinical lymph node metastasis

SUBMITTER: Uemura S 

PROVIDER: S-EPMC12757159 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature