Significance of Serum Tumor Markers in Esophageal and Gastric Cancers: A Systematic Literature Review.

ABSTRACT:

Aim

Serum tumor markers are helpful for diagnosis, monitoring treatment outcomes, and prognosis. However, their clinical utility for esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) remains unclear. This study aimed to comprehensively evaluate recent studies on serum tumor markers in ESCC and GC.

Methods

We conducted a systematic review and meta-analysis of studies published between January 2010 and March 2025 using PubMed. Overall, 84 and 468 articles on ESCC and GC were extracted, respectively. The sensitivity, specificity, positive predictive value, and summary receiver operating characteristic curves were calculated and evaluated using a systematic review and meta-analysis. Prognostic values were assessed using the hazard ratio based on univariate and mu

SUBMITTER: Matsumoto Y 

PROVIDER: S-EPMC12757164 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature