Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19.

ABSTRACT: Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) represent an urgent public health challenge and are estimated to affect more than 60 million individuals globally. Although a growing body of evidence suggests that dysregulated immune reactions may be linked with PASC symptoms, most investigations have primarily centered around blood-based studies, with few focusing on samples derived from affected tissues. Furthermore, clinical studies alone often provide correlative insights rather than causal mechanisms. Thus, it is essential to compare clinical samples with relevant animal models and conduct functional experiments to understand the etiology of PASC. In this study, we comprehensively compared bronchoalveolar lavage fluid single-cell RNA

SUBMITTER: Li C 

PROVIDER: S-EPMC12757174 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature