The Cost-Effectiveness of Collagenase Injection Versus Limited Fasciectomy for Moderate Dupuytren's Contracture: An Economic Evaluation of the Dupuytren's Interventions Surgery Versus Collagenase Trial and a Decision Analytical Model.

ABSTRACT:

Objectives

To compare the cost-effectiveness of collagenase injection (collagenase) and limited fasciectomy (LF) surgery in treating moderate Dupuytren's contracture (DC) in the United Kingdom over different time horizons.

Methods

An incremental cost-effectiveness analysis was conducted alongside a multicenter, pragmatic, parallel randomized controlled trial (Dupuytren's Interventions: Surgery versus Collagenase trial), to determine the short-term cost-effectiveness of collagenase compared with LF. A Markov decision analytic model was developed to assess long-term cost-effectiveness.

Results

Collagenase was associated with significantly lower cost and insignificantly lower quality-adjusted life-year (QALY) gain compared with LF at 1 year. The probability of collagenas

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12757186 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature