LAT1 expression in head and neck cancer: a prognostic biomarker with potential relevance for BNCT.

ABSTRACT:

Purpose

The increased expression of LAT1, an amino acid transporter, in cancer cells makes boronophenylalanine (BPA) uptake higher in cancer vs. healthy tissues: a high LAT1 expression on cancer cells implies a higher sensitivity to boron neutron capture therapy (BNCT). We explored the LAT1 expression in a cohort of head and neck cancer (HNSCC) patients, stratifying them according to a previously published transcriptomic 6-cluster model.

Methods

We analyzed 100 HNSCC patients treated with multimodal treatments including radiotherapy. Transcriptomics of primary tumor specimens was obtained by Affymetrix ClariomD chips and processed using the Transcriptome Analysis Console Software (ThermoFisher). We retrieved normalized and log2 LAT1 from the data matrix. Data were use

SUBMITTER: Cavalieri S 

PROVIDER: S-EPMC12757229 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature