Protective effects of polysaccharide SH-P-1-1 isolated from <i>Phellinus igniarius</i> on hyperuricemia and gout via intestinal microecosystem regulation.

ABSTRACT:

Introduction

Although Phellinus igniarius has been shown to treat hyperuricemia (HUA) and gout, a self-inflammatory disease caused by purine metabolism disorders, the underlying mechanisms remain unclear. Polysaccharides are among the main components of P. igniarius with anti-inflammatory and immunoregulatory properties.

Methods

Here, we examined the therapeutic effects of polysaccharide SH-P-1-1 isolated from P. igniarius on HUA and gout, and explored the underlying mechanism, focusing on gut microbiota and metabolite regulation.

Results

SH-P-1-1 significantly decreased uric acid and creatinine levels, reduced xanthine oxidase and adenosine deaminase activities, alleviated kidney damage, and reduced urate deposition in joints in model rats. It in

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12757238 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature