Tumour immune microenvironment prognostic factors in locally advanced rectal cancer, a systematic review.

ABSTRACT:

Introduction

Understanding factors influencing individual survival outcomes following surgical resection of locally advanced (LARC) rectal cancer remains challenging. Novel biomarkers could show emerging promise in this setting. This study aimed to systematically review the literature on immune prognostic factors in LARC.

Methods

The review protocol was preregistered on the PROSPERO database (CRD42023460541). Included studies were required to report overall survival and at least one immune prognostic factor for at least ten patients with LARC. Final searches of MEDLINE, EMBASE and Central were concluded on 8th September 2023. The risk of bias was assessed using the QUIPS tool.

Results

22 retrospective cohort studies involving 2,622 LARC patients were included in the r

SUBMITTER: Ball A 

PROVIDER: S-EPMC12757241 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature