Severe systemic cutaneous adverse reactions following camrelizumab therapy: a case report and literature review.

ABSTRACT: We report a case of a 42-year-old female patient with lip squamous cell carcinoma who developed a severe systemic cutaneous adverse reaction following camrelizumab therapy. The patient had previously undergone wide local excision, chemotherapy, and radiotherapy before receiving camrelizumab in combination with transcatheter arterial chemoembolization. Ten days after the initial infusion, she presented with generalized desquamation, hyperpigmented lesions, and skin breakdown involving the trunk and extremities, most prominently on the hands, arms, and legs. Corticosteroid therapy led to a rapid reduction in pruritus and gradual improvement of cutaneous lesions, with marked healing observed after one week. Remarkably, upon rechallenge with camrelizumab, only mild residual hyperpigmentation w

SUBMITTER: Sun YD 

PROVIDER: S-EPMC12757287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature