Immunomodulation by bacterial products promotes innate signatures favorable to macrophage responses in tuberculosis infection.

ABSTRACT:

Background

Tuberculosis remains a leading cause of death from infectious diseases globally, underscoring the need to boost innate responses in monocytes and macrophages to enhance early control of Mycobacterium tuberculosis infection. Trained immunity, a form of innate immune memory, enhances macrophage responsiveness through epigenet ic and metabolic reprogramming, offering a promising approach to strengthen host defenses against M. tuberculosis.

Methods

This study evaluated the immunomodulatory potential of pharmaceutical-grade bacterial suspension (BS) and bacterial lysates (BL) in human monocyte-derived macrophages (MDM) and their role in innate response to M. tuberculosis infection. MDMs were stimulated with M. bovis BCG, BS, and BL following a training protocol describ

SUBMITTER: Romero-Rodriguez DP 

PROVIDER: S-EPMC12757357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature