Plasma cell-free DNA genome-wide methylation profiling enables detection and activity assessment in systemic lupus erythematosus.

ABSTRACT:

Introduction

Cell-free DNA (cfDNA) has emerged as a promising non-invasive biomarker in precision medicine and is increasingly recognized as relevant to relevance in systemic lupus erythematosus (SLE), where elevated plasma cfDNA levels have been consistently observed. However, the cfDNA methylation pattern in SLE is unclear.

Methods

Differentially expressed genes (DEGs) and differentially methylated probes (DMPs) related to SLE were obtained from the Gene Expression Omnibus (GEO) database. Through multi-omics approaches, the immune microenvironment in renal tissues, whole blood, and peripheral blood mononuclear cells from SLE patients was integrated and analyzed. Applying whole-genome bisulfite sequencing technique, we evaluated the epigenomic features of plasma cfDNA methy

SUBMITTER: Liu YJ 

PROVIDER: S-EPMC12757368 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature