In-host co-colonization and bloodstream infection by distinct classical and hypervirulent CRKP clones harboring a homologous <i>bla</i> <sub>KPC-2</sub>-harboring plasmid.
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ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) readily colonizes clinical environments as well as the respiratory and intestinal tracts of patients and can easily cause secondary infections, posing a serious threat to infection treatment and hospital infection control. In this study, we continuously tracked CRKP strains isolated from a single patient over a total of 16 weeks-from admission to the ICU until discharge from the general ward. A total of 21 CRKP strains were obtained, including 1 bloodstream infection (BSI) isolate, 8 respiratory tract colonization isolates, and 12 intestinal colonization isolates. All isolates were evaluated for their phenotypic characteristics related to antimicrobial resistance, pathogenicity, and plasmid transfer through antimicrobial susceptibili
SUBMITTER: Fang H
PROVIDER: S-EPMC12757419 | biostudies-literature | 2025
REPOSITORIES: biostudies-literature
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