Genetically Validated Immune Susceptibility Markers for Crohn's Disease: A Multi-Omics Mendelian Randomization Analysis.

ABSTRACT:

Background

Crohn's disease (CD) is a chronic inflammatory bowel disorder with a multifactorial genetic, immune, and environmental basis, yet robustly validated therapeutic targets remain limited. We applied a multi-omics Mendelian randomization (MR) framework and colocalization to prioritize genetically supported immune susceptibility loci for CD.

Methods

A two-sample MR framework was used, integrating protein quantitative trait loci (pQTL) and expression quantitative trait loci (eQTL) datasets with genome-wide association study (GWAS) data on CD from the Finnish biobank. After identifying 994 pQTL genes, 610 genes overlapping with known druggable targets were selected. Causal associations with CD were evaluated using inverse variance weighted (IVW) MR. Significant hits were

SUBMITTER: Li Z 

PROVIDER: S-EPMC12757437 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature