Drug-Coated Balloons Versus Other Percutaneous Coronary Intervention Strategies in De Novo Coronary Artery Disease: A Systematic Review, Meta-Analysis With Trial Sequential Analysis.

ABSTRACT:

Background

Drug-coated balloons (DCBs) present a viable option distinct from drug-eluting stents (DESs) in addressing coronary artery disease (CAD), particularly when it comes to in-stent restenosis (ISR) scenarios. The utilization of DCBs marks a significant deviation from traditional DES applications. For CAD patients experiencing ISR, DCBs offer an innovative pathway to treatment. However, their efficacy and safety in de novo CAD lesions remain uncertain. This meta-analysis evaluates DCB versus other percutaneous coronary intervention (PCI) strategies, including DES, bare-metal stents (BMSs), and plain old balloon angioplasty (POBA), in de novo CAD.

Methods

A comprehensive search was conducted across PubMed, Embase, Web of Science, and the Cochrane Central Register of Con

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12757438 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature