Multiomics Data Synthesis of FAM83H in Amelogenesis Imperfecta.

ABSTRACT:

Objectives

FAM83H is a critical gene implicated in amelogenesis imperfecta type IIIA (AI type IIIA), but its precise role in enamel formation remains poorly understood. Fragmented datasets, inconsistent terminology, and limited integrative analyses hinder functional interpretation. This study presents a comprehensive multi-omics analysis of FAM83H-associated AI type IIIA.

Methods

A systematic literature search (February 2008-June 2025) was conducted in PubMed and Web of Science using targeted keywords spanning genomics, transcriptomics, epigenomics, miRNomics, proteomics, interactomics, epiproteomics, metabolomics, glycomics, lipidomics, intracellular localization, phenomics, pharmacogenomics, and environmental omics. Data were extracted using 13 bioinformatic tools and data

SUBMITTER: Leban T 

PROVIDER: S-EPMC12757458 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature