Post-transcriptional effects of <i>leptin</i> 3'UTR polymorphisms on Milk traits in dairy cattle.

ABSTRACT: Leptin plays a central role in regulating energy balance and lactation in dairy cattle. This study aimed to identify single nucleotide polymorphisms (SNPs) in the coding and 3' untranslated regions (3'UTR) of the leptin gene, evaluate their associations with milk production traits, and functionally validate the regulatory effects of key 3'UTR variants on gene expression. Genotyping of 1337 Chinese Holstein cows revealed that c.120 T > C, c.1215 T > C, and c.1761 G > A were polymorphic. The c.120 T > C and c.1215 T > C loci were associated with milk fat, protein, and urea nitrogen levels, whereas c.1761 G > A was associated with increased 305-day milk yield, with cows carrying the GG genotype producing approximately 500 kg more milk than those with the AA genotype. Bioinformatic anal

SUBMITTER: Li M 

PROVIDER: S-EPMC12757460 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature