Photoelectrical control of apoptosis and autophagy.

ABSTRACT: Controlling cancer cell fate through membrane depolarization, reactive oxygen species (ROS) dynamics, and voltage-gated ion channel (VGIC) activation represents a rapidly advancing paradigm in bioelectronic oncology. Electrically excitable cancer cells-including glioblastoma, retinoblastoma, SH-SY5Y neuroblastoma, MCF-7, and MDA-MB-231-exhibit distinct electrophysiological and redox sensitivities that govern their responsiveness to photoelectrical stimulation. Here, we develop an integrated theoretical and transcriptomic framework describing how photocapacitive and photofaradaic stimulation modulates intracellular calcium signaling, mitochondrial membrane potential (ΔΨm), and ROS homeostasis to determine apoptotic, autophagic, or proliferative outcomes. Experimental data sets from GSE59612

SUBMITTER: Mohammadiaria M 

PROVIDER: S-EPMC12757480 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature