Modeling the seasonal and climate-dependent dynamics of visceral leishmaniasis in Brazil: Implications for transmission and Control.

ABSTRACT:

Background

Visceral leishmaniasis (VL) is a parasitic, zoonotic neglected tropical disease that remains a persistent public health challenge in endemic regions of Brazil, including the state of Maranhão. Transmission dynamics are complex, involving interactions between Lutzomyia longipalpis sandflies, canine reservoirs, and human hosts, and are influenced by environmental and climatic variability. Mathematical models are critical tools for understanding these dynamics and identifying opportunities to effectively disrupt transmission.

Methods

Our objective was to develop and calibrate a climate-informed mechanistic model of VL transmission in Maranhão, Brazil, and to evaluate the potential impacts of vector, environmental, and reservoir-targeted interventions. The mode

SUBMITTER: Adams QH 

PROVIDER: S-EPMC12757486 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature