Genome-wide association study of economic traits and functional characterization of MAN2A2 in the Jilin White Goose.

ABSTRACT: Egg-laying and growth traits play a critical role in determining the economic value of geese. This study integrates a genome-wide association study with functional analyses to elucidate the genetic basis of these traits in the Jilin White Goose. We systematically phenotyped 200 geese for key egg-laying traits, such as total egg number and average egg-laying interval, as well as growth traits, including body weight and tibia length. The GWAS, utilizing whole-genome resequencing, identified 766 significant single nucleotide polymorphisms. Notably, a non-synonymous mutation (chr19:361983:C:A) within the MAN2A2 gene was strongly associated with average egg-laying interval. Other significant loci included UBE2R2, which is associated with body weight, and NTN1/SLC2A9, linked to tibia length. Fun

SUBMITTER: Song Y 

PROVIDER: S-EPMC12757490 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature