TIGAR promotes osteogenic differentiation and ameliorates glucocorticoid-induced osteoporosis via autophagy-Nrf2-ROS axis.

ABSTRACT: Glucocorticoid-induced osteoporosis (GIOP) is a public health problem that needs urgently to be resolved, and oxidative stress is closely related to osteogenic impairment. TP53-induced glycolysis and apoptosis regulator (TIGAR) contributes to the occurrence and development of various diseases by reducing reactive oxygen species (ROS). However, it is unknown whether and how TIGAR plays a regulatory role in GIOP. The aim of the present study is to investigate the role of TIGAR in osteogenic differentiation and the underlying molecular mechanism. We explored the protective role and mechanism of TIGAR on osteogenic differentiation and GIOP by using the TIGAR overexpression plasmid and siRNA in vitro, and by constructing systemic TIGAR overexpression (TG-TIGAR) mice in vivo, respe

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12757533 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature