Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation.

ABSTRACT: The acute inflammatory response is a highly coordinated protective process governed by a superfamily of mediators termed specialized proresolving mediators. This includes the recently uncovered 17R-Resolvin D2 (17R-RvD2). We report 17R-RvD2 is rapidly metabolized and locally inactivated by human macrophages. An analog was prepared in a stereospecific synthesis. This benzo-17R-RvD2 resists rapid enzymatic inactivation and shared 17R-RvD2's pro-resolving actions enhancing human macrophage efferocytosis (pico-nanomolar). In peritonitis, benzo-17R-RvD2 (1 ng/mouse; 2.7 pmol) limited neutrophil infiltration >70%, reduced tumor necrosis factor alpha (TNF-α), and increased interleukin-1 (IL-1) receptor antagonist. The analog (1 nM) also enhanced >50% Escherichia coli killing by human leuko

SUBMITTER: Serhan CN 

PROVIDER: S-EPMC12757561 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature