Association between mean platelet volume and kidney events in patients with type 2 diabetes mellitus.

ABSTRACT:

Introduction

Mean platelet volume (MPV), which reflects platelet size and activity, is known to be elevated in patients with type 2 diabetes mellitus. Although increased MPV has been linked to poor glycemic control and diabetic vascular complications, evidence regarding its association with hard kidney outcomes remains limited. We aimed to investigate the relationship between MPV and kidney events in patients with type 2 diabetes mellitus.

Materials and methods

We retrospectively analyzed longitudinal data from 1,076 Japanese patients with type 2 diabetes mellitus enrolled in the Fukushima Cohort Study. Participants were categorized into quartiles based on baseline MPV levels. The primary endpoint was kidney events, defined as a ≥50% decline in estimated glomerular filtratio

SUBMITTER: Watanabe S 

PROVIDER: S-EPMC12757671 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature