Development of a Physiologically Based Pharmacokinetic (PBPK) Simulation Model for Nicotine.

ABSTRACT: Tobacco is a major cause of chronic diseases such as lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease worldwide. Nicotine, the primary psychoactive component in tobacco, is highly addictive and while not the primary driver of such tobacco-related diseases, poses various health risks, particularly those affecting the cardiovascular and pulmonary systems. Although nicotine-based therapies, such as nicotine replacement products, are widely utilized in smoking cessation efforts today, the impact of newer, tobacco delivery systems such as electronic nicotine delivery systems, or ENDS, remains uncertain and warrants continued evaluation. This study aims to develop and validate a physiologically based pharmacokinetic (PBPK) simulation model for nicotine using clinica

SUBMITTER: Kim B 

PROVIDER: S-EPMC12757703 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature