CRB2 Activates an Epigenetic Axis to Promote Ferroptosis in Head and Neck Squamous Cell Carcinoma.

ABSTRACT: Therapeutic activation of ferroptosis is a potential strategy to induce cell death in cancer. Deciphering the epigenetic regulation of ferroptosis could provide insights into effective approaches for enhancing ferroptosis in cancer cells. In this study, we identified CRB2 as an epigenetic modulator of ferroptosis in head and neck squamous cell carcinoma (HNSCC). CRB2 expression correlated with the expression of ferroptosis-related genes and improved prognosis in patients with HNSCC. Ferroptosis inducers erastin and RSL3 significantly increased CRB2 expression, and overexpression of CRB2 sensitized HNSCC to ferroptosis, suppressing growth in vitro and in vivo. CRB2 upregulation led to an increase in the dimethylation of histone H4 lysine 20 in the promoter region of the ferroptosis inhibito

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12757720 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature