Mechanistic insights into drying methods: how they govern the structure and bioactivity of resveratrol-HP-β-CD inclusion complexes.

ABSTRACT: Resveratrol (RES), a polyphenol with notable therapeutic potential, faces clinical limitations due to poor water solubility and low bioavailability. This study aimed to enhance the solubility and stability of RES by forming inclusion complexes with hydroxypropyl-β-cyclodextrin (HP-β-CD) using three drying methods: spray drying (SD), freeze-drying (FD), and solvent evaporation (SE). Phase solubility analysis confirmed the successful formation of a stable complex (K = 5278 M^-1) at an optimal 1:2 RES: HP-β-CD ratio. Among the dried products, the spray-dried complex (RHSD) demonstrated superior performance in moisture content, yield, and resveratrol content. It achieved the highest solubility enhancement (89-fold increase). In contrast, the freeze-dried complex (RHFD) showed the mos

SUBMITTER: Marwa A 

PROVIDER: S-EPMC12757797 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature