[BMIM]OAc promoted one-pot synthesis of pyrazolo[4',3':5,6]pyrido[2,3-<i>d</i>]pyrimidin-5-ones and their antimicrobial activity.

ABSTRACT: A one-pot method was developed for synthesizing pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidin-5-ones using the recyclable ionic liquid catalyst [BMIM]OAc in ethanol under reflux conditions. This approach achieved high yields (76-95%) across various substrates along with straightforward product isolation and catalyst recyclability. The synthesized compounds 4(a-l) were tested for antimicrobial activity against Gram-positive and Gram-negative bacteria, and fungal strains. Notably, compounds 4c and 4e showed strong antibacterial effects against S. aureus (MIC: 8 µg mL^-1), while 4a, 4b, and 4f effectively inhibited E. coli (MIC: 8 µg mL^-1). Compound 4l exhibited notable antifungal activity against C. albicans (MIC: 8 µg mL^-1), outperform

SUBMITTER: Bhalodiya SS 

PROVIDER: S-EPMC12757851 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature