The Impact of <i>Chlamydia trachomatis</i> on Male Infertility: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Chlamydia trachomatis (CT) is a common sexually transmitted infection, yet its contribution to male infertility remains incompletely understood.

Methods

A systematic review and meta-analysis of case-control studies were conducted following PRISMA guidelines. Literature from PubMed/MEDLINE, Scopus, Cochrane, and Embase (2000 onward) was screened. Random-effects models were used in R, with subgroup analyses by geography, case definition, diagnostics, and matching criteria.

Results

Out of 2941 records, 26 case-control studies (11 706 participants) met inclusion criteria. Most studies used molecular diagnostics (n = 23). A significant association was found between CT infection and male infertility (odds ratio [OR] 3.68 [95% CI 2.24-6.02]), with substanti

SUBMITTER: Bragazzi NL 

PROVIDER: S-EPMC12757865 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature