Cyanobacterial Extracellular Vesicles as Protein Carriers: Towards Fish Vaccination.

ABSTRACT: Fish aquaculture faces significant economic losses from disease outbreaks. Vaccination is the most effective prevention strategy, and bacterial extracellular vesicles (EVs) show promise as vaccine platforms due to their strong immuno-stimulating properties. However, the application of EVs derived from pathogenic bacteria is limited by toxicity risks and production challenges. Alternatively, genetic engineering of non-pathogenic microorganisms is being explored to produce tailored EVs to deliver antigens and serve as carriers of therapeutic proteins. Recently, we have engineered the model cyanobacterium Synechocystis sp. PCC 6803 for the expression of the reporter green fluorescent protein (sfGFP) and its targeting to EVs. Here, taking advantage of the Synechocystis sfGFP-loaded EVs, the st

SUBMITTER: Matinha-Cardoso J 

PROVIDER: S-EPMC12757927 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature