Abnormal Resting-State Functional Connectivity Between the Dorsal Anterior Cingulate Cortex and the Limbic System Contributes to Pain and Emotion Regulation Impairment in Fibromyalgia Patients.

ABSTRACT:

Objectives

The subdivisions of the anterior cingulate cortex (ACC) are involved in distinct functions in the processing of chronic pain and regulation of emotions. However, the specific impact of each ACC subdivision on fibromyalgia (FM) remains unclear. This study aimed to systematically investigate the abnormal resting-state functional connectivity (rsFC) patterns between the ACC (and its subregions) and other chronic-pain-related limbic cortices and subcortical nuclei in patients with FM.

Methods

Resting-state functional magnetic resonance imaging (fMRI) was conducted in 31 patients diagnosed with fibromyalgia (FM) and 32 demographically matched healthy controls (HCs). Using subdivisions of the anterior cingulate cortex (ACC) as regions of interest, we employed a seed-bas

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12757978 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature