Difficulties following naturalistic psychedelic use and associations with adverse childhood experiences.

ABSTRACT:

Background

Naturalistic psychedelic use can result in a range of difficulties that impair social, occupational, and other important areas of functioning. Yet, the prevalence, phenomenology, and etiology of these outcomes remain poorly understood. Recent qualitative research has shown that individuals with long-term difficulties after psychedelic use sometimes attribute their challenges to childhood trauma. Further studies are needed to investigate these relationships.

Methods

In this cross-sectional mixed-methods study of U.S. adults with lifetime psychedelic use (n = 3168), we examined the prevalence, duration, and nature of psychedelic-related difficulties, as well as associations with adverse childhood experiences (ACEs).

Results

Of all participants (n = 3168), mos

SUBMITTER: Olofsson M 

PROVIDER: S-EPMC12758006 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature