Pregnancy outcomes in idiopathic inflammatory myopathies: a Portuguese multicentre study.

ABSTRACT:

Introduction

Idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases that may complicate pregnancy, but evidence remains scarce. Disease activity at conception and during gestation, together with autoantibody profiles, are considered major determinants of adverse pregnancy outcomes (APOs).

Methods

We conducted a retrospective multicentre study of 12 pregnancies in 10 women with IIM followed at four Portuguese tertiary centers (2009-2025). Demographic, clinical, immunological, therapeutic, maternal, and perinatal data were collected from medical records. Disease activity was assessed by clinical features, laboratory data, modified skin Disease Activity Score, and Manual Muscle Testing-8.

Results

Phenotypes included overlap myositis (n = 4), antisyn

SUBMITTER: Lopes AR 

PROVIDER: S-EPMC12758025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature