Metabolic Regulatory Mechanism of Gastric Motility by Acetylcholine.

ABSTRACT:

Background

Acetylcholine (ACh), a crucial neurotransmitter for gastric contractions, induces triphasic contraction in stomach. However, the precise mechanism of ACh-induced phasic contractions (AiPCs) remains unclear. Recent data suggest the chloride channel (Cl^- channel) may be the principal channel for AiPC in the stomach. Previous studies demonstrated that the opening of the ATP-sensitive potassium (K_ATP) channel inhibits AiPC. However, it has not been studied whether inhibition of energy metabolism can regulate AiPC in gastric smooth muscles via this channel. This study investigated whether AiPC in gastric smooth muscle are mediated by chloride channels and modulated by K_ATP channels under conditions of energy metabolism inhibition.

Methods</

SUBMITTER: Lee JY 

PROVIDER: S-EPMC12758062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature