<i>HFE</i>-C282Y/C282Y Hemochromatosis Patients Have Lower Serum Transferrin and Strong Negative Correlations Between Iron, Ferritin, and Transferrin Saturation Versus Transferrin Compared With <i>HFE</i>-wt/wt Wild-Type Subjects.

ABSTRACT:

Background

HFE-C282Y/C282Y hemochromatosis patients have lower serum transferrin levels than normal individuals, but the reason for this discrepancy has drawn little scientific attention and remains unclarified. The objective of this study was to examine transferrin levels and their correlations with other biochemical iron status markers in Danish patients with the C282Y/C282Y variant and compare with corresponding correlations in a population of healthy Danes with the HFE-wt/wt genotype.

Methods

The study comprised 21 patients (11 men) who completed a questionnaire about age, number of years with hemochromatosis, and at least 10 consecutive blood sample results, including ferritin, iron, transferrin and transferrin saturation (TSAT). The control group consiste

SUBMITTER: Milman NT 

PROVIDER: S-EPMC12758079 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature